LEXINGTON, Mass., September 9, 2008 – GI Dynamics, a medical device company pioneering the development of new approaches to treating metabolic disorders, today announced that new data regarding EndoBarrier™, its novel, noninvasive device currently in clinical trials to treat obesity and type 2 diabetes, will be presented at the First World Congress on Interventional Therapies for Type 2 Diabetes in New York City.

The session, entitled “Novel Gastrointestinal Interventional Therapies,” will be chaired by Lee M. Kaplan, M.D., Ph.D., associate professor of medicine and director of the Weight Center at Massachusetts General Hospital, on Tuesday, September 16, 2008 at 11:00 a.m. (EDT). Dr. Kaplan will present a keynote lecture “Endoluminal Therapies for Type 2 Diabetes” that will include new data from a prospective, randomized, sham-controlled clinical trial investigating the EndoBarrier Gastrointestinal Liner.

“We look forward to participating in this first-ever conference on interventional approaches to treating type 2 diabetes,” stated Stuart A. Randle, chief executive officer of GI Dynamics. “This disease has reached epidemic proportions around the globe, and while significant strides have been made to bring new pharmacologic remedies to market, there exists a substantial unmet need for a simple and safe approach for patients to achieve metabolic control. Recent data emerging from more invasive procedures like gastric bypass surgery are promising; however, we believe EndoBarrier has the potential to provide immediate metabolic control with less risk. We look forward to further discussion of our data at this conference.”

About GI Dynamics

GI Dynamics, a clinical-stage medical device company, is pioneering the development of new, noninvasive approaches to treat obesity, type 2 diabetes and related metabolic diseases. The Company’s patented EndoBarrier™ technology is designed to deliver immediate metabolic control by modifying metabolic pathways. GI Dynamics has developed the EndoBarrier™ Gastrointestinal Liner, an orally delivered, removable device that lines a portion of the small intestine, resulting in weight loss and improved glycemic control. Based in Lexington, Massachusetts and founded in 2003, GI Dynamics is backed by top-tier investors including Advanced Technology Ventures, Catalyst Health Ventures, Cutlass Capital, Domain Associates, Johnson & Johnson Development Corporation and Polaris Venture Partners. For more information, visit GI Dynamics online at www.gidynamics.com.

About the 1st World Congress on Interventional Therapies for Type 2 Diabetes

The 1st World Congress on Interventional Therapies for Type 2 Diabetes is a comprehensive and multidisciplinary forum where leaders in the global health community will conduct an organized review and discussion of the latest scientific data and theories on the use of bariatric surgery for the treatment of type 2 diabetes. The Congress, hosted by Weill Cornell Medical College and New York-Presbyterian Hospital, aims to create a forum for the medical community to work with health policy makers, including top public health authorities and insurers from the U.S. and around the world. The overarching aim is to craft an agenda of health policy initiatives to seize the opportunity offered by gastrointestinal surgery and novel interventional therapies for the understanding and treatment of diabetes. The 1st World Congress will be held on September 15-16, 2008, at the New York Marriot Marquis in Times Square.