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Publications and Abstracts

Please see below a selection of links to scientific publications and presentations about GI Dynamics’ EndoBarrier® Therapy, the first endoscopically-delivered device therapy approved for type 2 diabetes and obesity.

2013

"A pilot study of the duodenal-jejunal bypass liner in low body mass index type 2 diabetes." Cohen RV, Neto MG, Correa JL, Sakai P, Martins B, Schiavon CA, Petry T, Salles JE, Mamedio C, Sorli C. J Clin Endocrinol Metab. 2013 Feb;98(2):E279-82.

"Endoscopic Duodenal-Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes." de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Schaper NC, Bouvy ND, Greve JW. Obesity Surgery, Sept. 2013, Volume 23, Issue 9, pp 1354-1360

“Endoscopic Duodenal−Jejunal Bypass Liner Rapidly Improves Plasma Parameters of Nonalcoholic Fatty Liver Disease” de Jonge C, Rensen SS, Koek GH, Joosten MF, Buurman WA, Bouvy ND, Greve JW., Clin Gastroenterol Hepatol. 2013 Aug 3. pii: S1542-3565(13)01093-8

“The feasibility of delivering a duodenal-jejunal bypass liner (endobarrier) endoscopically with patients under conscious sedation.” Koehestanie P, Betzel B, Dogan K, Berends F, Janssen I, Aarts E, Groenen M, Wahab P., Surg Endosc. 2013 Aug 27.

“Pathophysiology Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes.” Cohen R, le Roux CW, Papamargaritis D, Salles JE, Petry T, Correa JL, Pournaras DJ, Galvao Neto M, Martins B, Sakai P, Schiavon CA, Sorli C., Diabet Med. 2013 Jun 26

“The duodenal-jejunal bypass sleeve (EndoBarrier Gastrointestinal Liner) for weight loss and treatment of type 2 diabetes.” Patel SR, Hakim D, Mason J, Hakim N., Surg Obes Relat Dis. 2013 May-Jun;9(3):482-4.

"Baseline glycated hemoglobin levels are associated with duodenal-jejunal bypass liner-induced weight loss in obese patients." Muñoz R, Dominguez A, Muñoz F, Muñoz C, Slako M, Turiel D, Pimentel F, Sharp A, Escalona A. Surg Endosc. 2013 Nov 7. [Epub ahead of print]

2012

"Metabolic Improvements in Obese Type 2 Diabetes Subjects Implanted for 1 Year with an Endoscopically Deployed Duodenal–Jejunal Bypass Liner.” Diabetes Technology & Therapeutics, 2012. E. G.H. de Moura, B. C. Martins, G. S. Lopes, I. R. Orso, S. L. de Oliveira, M. P. Galvão Neto, M. A. Santo, P. Sakai, A. C. Ramos, A. B. Garrido Júnior, M. C. Mancini, A. Halpern, I. Cecconello.

“Six month results of a multi-center, prospective, randomized trial of the endoscopic Duodenal-Jejunal Bypass Liner for the treatment of type 2 diabetes in obese subjects.” Presented at the American Diabetes Association (ADA) 72nd Scientific Sessions, 2012. P. Koehestanie, B. Meesters, I.M.C. Janssen, N. Bouvy, J.W. Greve.

“Mechanisms for improved glycemic control after endoscopically placed Duodenal-Jejunal Bypass Liner.” Presented at the American Diabetes Association (ADA) 72nd Scientific Sessions, 2012. R.V. Cohen, C.W. le Roux, D. Papamargaritis, J. Salles, T. Petry, J.L. Correa, M.G. Neto, B. Martins, P. Sakai, C.A. Schiavon, C. Sorli.

"Weight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner." Annals of Surgery, 2012. A. Escalona, F. Pimentel, A. Sharp, P. Becerra, M. Slako, D. Turiel, R. Mun ̃oz, C. Bambs, S. Guzma ́n, L. Iba ́n ̃ez, and K. Gersin."

“Isolated Duodenal Exclusion Increases Energy Expenditure and Improves Glucose Homeostasis in Diet-induced Obese Rats.” Am J Physiol Regul Integr Comp Physiol, 2012. R. Muñoz, J.S. Carmody, N. Stylopoulos, P. Davis, L.M. Kaplan.

“Implantation of the duodenal-jejunal bypass sleeve under conscious sedation: a case series.” Surgery for Obesity and Related Diseases, 2012. R. Montaña, M. Slako, A. Escalona.

2010

"Open-label, sham-controlled trial of an endoscopic duodenojejunal bypass liner for preoperative weight loss in bariatric surgery” Gastrointestinal Endoscopy, 2010. K Gersin, R Rothstein, R Rosenthal, D Stefanidis, S Deal, T Kuwada,W Laycock, G Adrales, M Vassiliou, S Szomstein, S Heller, A Joyce, F Heiss, D Nepomnayshy.

“Initial Human Experience with a Restrictive Duodenal- Jejunal Bypass Liner for the Treatment of Morbid Obesity.” Surgery for Obesity and Related Diseases, 2010. A Escalona, R Yanez, F Pimentel, M Galvao, A Ramos, D Turiel, C Boza, D Awruch, K Gersin, L Ibanez.

2009

“Pilot Clinical Study of an Endoscopic, Removable Duodenal-Jejunal Bypass Liner for the Treatment of Type 2 Diabetes.” Diabetes Technology and Therapeutics, November 2009. L Rodriguez, E Reyes, P Fagalde, M Oltra, J Saba, C Aylwin, C Prieto, A Ramos, M Galvao, K Gersin, C Sorli.

2008

“First human experience with endoscopically delivered and retrieved duodenal-jejunal bypass sleeve.” Surgery for Obesity and Related Diseases, 4 (2008): 55-59. L Rodriguez, M Galvao, M Alamo, A Ramos, P Brante, M Tarnoff.

“An Endoluminal Sleeve Induces Substantial Weight Loss and Normalizes Glucose Homeostasis in Rats with Diet-Induced Obesity.” Obesity (2008) 16 12, 2585–2592. doi:10.1038/oby.2008.502. V Aguirre, N Stylopoulos, R Grinbaum, L M Kaplan.