A groundbreaking solution for restoring healthy blood sugar levels, losing weight and regaining control.

EndoBarrier® is the first treatment of its kind: an endoscopically-delivered device for people living with uncontrolled type 2 diabetes and obesity that bridges the gap between ineffective medications, undesirable injections, and drastic surgery. It’s safe. It’s reversible. And it’s providing long-term results to thousands of patients worldwide.

How it works

The EndoBarrier liner is a thin flexible liner placed inside the patient’s mouth and situated inside the intestine, just below the stomach. Placement is a simple procedure that does not require any incisions, in which a doctor inserts the EndoBarrier liner endoscopically through a patient’s mouth.

Once in place, the liner conforms to the shape and movement of the patient’s intestine and begins to work immediately. It does so by creating a physical barrier between  receptors in the intestinal wall and any food being digested releasing gut hormone signals. The result is increased satiety—or the feeling of being full—despite less food intake, as well as reduced blood sugar (glucose levels) and increased weight loss.

What it does

Clinical data suggests that EndoBarrier works by affecting key hormones involved in insulin sensitivity, glucose metabolism, satiety and food intake.1,2. Such results can allow for a reduction in oral diabetes medications and may prevent a progression to insulin. Additionally, in clinical studies, EndoBarrier has also been shown to improve cardiometabolic risks.2,3



EndoBarrier has been shown to1:

  • Lower glycaemia
  • Improve islet function
  • Stimulate gut hormone release
  • Improve incretin secretion and insulin sensitivity

The most commonly reported complications are gastrointestinal in nature. They include nausea, vomiting and upper abdominal pain of mild to moderate severity and are most prevalent in the early days and weeks following EndoBarrier placement. Other uncommon risks include infection, trauma, device migration and bleeding, any of which may result in endoscopic or surgical removal of the device. As with all endoscopic and/or implant procedures, serious injury or death can occur.

Removal and Results

Treatment with EndoBarrier liner may last up to 12 months, but may not exceed it. Liner removal is done via another brief endoscopic procedure, similar to the one used during placement.

Even after EndoBarrier treatment period ends, the benefits continue. In two separate studies following subjects after liner removal, 80% maintained achieved weight loss eight months’ post-removal and 77% maintained their weight loss 12 months’ post-removal. Even better, they did without the support of a formal directed diet or exercise program.



  1. ADA 2016 Poster: 1970-P “Increased Postprandial Glucagon-like Peptide-1 Responses in Obese Patients with Type 2 Diabetes Implanted for 26 Weeks with the EndoBarrier Gastrointestinal Liner” Ulrich Rodhe, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
  2. ENDO ’16, Boston, MA “One Year Efficacy, Safety and Tolerability Outcomes of Endoscopic Duodenal Exclusion Using EndoBarrier as an Adjunct to Glucagon-like Peptide-1 (GLP-1) Therapy in Sub-optimally Controlled Type 2 Diabetes: A Randomised Controlled Trial”, Robert E. Ryder, et al., Sandwell and West Birmingham Hospitals NHS Trust
  3. ADA 76th Scientific Sessions June 2016 “The Effect of 1-Year’s Endoscopic Proximal Intestinal Exclusion Using EndoBarrier on 10-Year Cardiovascular Risk in Type 2 Diabetes” Robert E. Ryder, et al., Sandwell and West Birmingham Hospitals NHS Trust


Real People. Remarkable Results.

See first-hand how EndoBarrier is helping people the world over control their glucose, lose weight and reclaim their lives, without invasive surgery.

Source: ABCD EndoBarrier Study
 – Robert Ryder, MD, 2016, 2017